1. Effects of High Doses of Vitamin C
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2. Metabolomic alterations in human cancer cells by vitamin C
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Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress.
Uetaki M1,2, Tabata S1,2, Nakasuka F1,3, Soga T1,2,3, Tomita M1,2,3.
3. High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases
Yonsei Med J. 2015 Sep;56(5):1449-52. doi: 10.3349/ymj.2015.56.5.1449.
High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular Carcinoma.
Seo MS1,2, Kim JK3, Shim JY4.
4. Intravenous ascorbic acid and hydrogen peroxide in the management of patients with chikungunya
Bol Asoc Med P R. 2015 Jan-Mar;107(1):20-4.
Intravenous ascorbic acid and hydrogen peroxide in the management of patients with chikungunya.
Marcial-Vega V, Idxian Gonzalez-Terron G, Levy TE.
5. The effect of intravenous vitamin C on cancer
Front Oncol. 2014 Oct 16;4:283. doi: 10.3389/fonc.2014.00283. eCollection 2014.
The effect of intravenous vitamin C on cancer- and chemotherapy-related fatigue and quality of life.
Carr AC1, Vissers MC1, Cook JS2.
6 High-dose intravenous ascorbic acid in patients with advanced cancer
Stephenson CM, Levin RD, Spector T, Lis CG. Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer. Cancer Chemother Pharmacol (2013) 72(1):139–46.10.1007/s00280-013-2179-9
7. I.v. ascorbic acid in advanced malignancy
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8. Changes of terminal cancer patients’ health-related quality of life after high dose vitamin C
Yeom CH, Jung GC, Song KJ. Changes of terminal cancer patients’ health-related quality of life after high dose vitamin C administration. J Korean Med Sci (2007) 22(1):7–11.10.3346/jkms.2007.22.1.7
9. Intravenous vitamin C administration improves quality of life in breast cancer patients
Vollbracht C, Schneider B, Leendert V, Weiss G, Auerbach L, Beuth J. Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany. In vivo (2011) 25(6):983–90.
10. High-dose intravenous ascorbic acid in patients with advanced cancer
Stephenson CM, Levin RD, Spector T, Lis CG. Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer. Cancer Chemother Pharmacol (2013) 72(1):139–46.10.1007/s00280-013-2179-9
11. High-dose intravenous vitamin C improves quality of life in cancer patients
Takahashi H, Mizuno H, Yanagisawa A. High-dose intravenous vitamin C improves quality of life in cancer patients. Personalized Med Universe (2012) 2(1):49–53.10.1016/j.pmu.2012.05.008
12. Intravenous Vitamin C and Cancer
Integr Cancer Ther. 2014 May 26;13(4):280-300.
Intravenous Vitamin C and Cancer: A Systematic Review.
Fritz H1, Flower G2, Weeks L2, Cooley K3, Callachan M1, McGowan J1, Skidmore B1, Kirchner L4, Seely D5.
13. Relief from cancer chemotherapy side effects with pharmacologic vitamin C
Carr AC, Vissers MC, Cook J. Relief from cancer chemotherapy side effects with pharmacologic vitamin C. NZ Med J (2014) 127(1388):66–70.
14. Parenteral vitamin C for palliative care of terminal cancer patients
Carr AC, Vissers MCM, Cook J. Parenteral vitamin C for palliative care of terminal cancer patients. NZ Med J (2014) 127(1396):84–6.
15. Effect of high dose vitamin C on Epstein-Barr viral infection
Med Sci Monit. 2014 May 3;20:725-32. doi: 10.12659/MSM.890423.
Effect of high dose vitamin C on Epstein-Barr viral infection.
Mikirova N1, Hunninghake R1.
16. Intravenous ascorbic acid in patients with severe sepsis
J Transl Med. 2014 Jan 31;12:32. doi: 10.1186/1479-5876-12-32.
Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis.
Fowler AA 3rd1, Syed AA, Knowlson S, Sculthorpe R, Farthing D, DeWilde C, Farthing CA, Larus TL, Martin E, Brophy DF, Gupta S; Medical Respiratory Intensive Care Unit Nursing, Fisher BJ, Natarajan R.
17. Intravenous administration of vitamin C in the treatment of herpetic neuralgia
Med Sci Monit. 2010 May;16(5):CS58-61.
Intravenous administration of vitamin C in the treatment of herpetic neuralgia: two case reports.
Schencking M1, Sandholzer H, Frese T.
18. Intravenous infusion of ascorbic acid decreases serum histamine
Naunyn Schmiedebergs Arch Pharmacol. 2013 Sep;386(9):789-93. doi: 10.1007/s00210-013-0880-1. Epub 2013 May 11.
Intravenous infusion of ascorbic acid decreases serum histamine concentrations in patients with allergic and non-allergic diseases.
Hagel AF1, Layritz CM, Hagel WH, Hagel HJ, Hagel E, Dauth W, Kressel J, Regnet T, Rosenberg A, Neurath MF, Molderings GJ, Raithel M.
19. Vitamin C revisited.
Oudemans-van Straaten HM, Spoelstra-de Man AM, de Waard MC.Crit Care. 2014 Aug 6;18(4):460. doi: 10.1186/s13054-014-0460-x.
Proc Natl Acad Sci U S A
20. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues
Qi Chen 1, Michael Graham Espey, Murali C Krishna, James B Mitchell, Christopher P Corpe, Garry R Buettner, Emily Shacter, Mark Levine
Adv Nutr. 2011 Mar;2(2):78-88. doi: 10.3945/an.110.000109. Epub 2011 Mar 10.
21 Vitamin C:
a concentration-function approach yields pharmacology and therapeutic discoveries. Mark Levine 1, Sebastian J Padayatty, Michael Graham Espey Proc Natl Acad Sci U S A. 2007 May 22;104(21):8749-54. doi: 10.1073/pnas.0702854104. Epub 2007 May 14.
22. Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo
Qi Chen 1, Michael Graham Espey, Andrew Y Sun, Je-Hyuk Lee, Murali C Krishna, Emily Shacter, Peter L Choyke, Chaya Pooput, Kenneth L Kirk, Garry R Buettner, Mark Levine. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11105-9. doi: 10.1073/pnas.0804226105. Epub 2008 Aug 4.
23 Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice
Qi Chen 1, Michael Graham Espey, Andrew Y Sun, Chaya Pooput, Kenneth L Kirk, Murali C Krishna, Deena Beneda Khosh, Jeanne Drisko, Mark Levine